Fibrosing cholestatic hepatitis in HBV transgenic mice after bone marrow transplantation

Introduction: Chronic hepatitis B virus (HBV) infection is associated with acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Fibrosing cholestatic hepatitis (FCH) is a severe form of HBV infection, usually seen in immunocompromised patients, including liver and bone marrow transplant recipients. The aim of this study was to investigate the impact of bone marrow transplantation (BMT) on hepatic injury and fibrosis in transgenic mice that express HBV surface (HBs) proteins in the liver. Methods:12-week-old BALB/c transgenic mice that express HBs proteinsin the liver were lethally irradiated and…