CareLit Fachartikel

TGF-β2 in Chronic Liver Disease (CLD) and Hepatocellular Carcinoma (HCC)

A Dropmann, A Piiper, EA Alonso, S Weber, K Abshagen, M Wieland, S Nittka, K Breitk-Heinlein, M Janicot, F Jaschinski, H Korhonen, S Dooley · Zeitschrift für Gastroenterologie · 2014 · Heft 01

Dokument
930653
CareLit-ID
Jahr
2014
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Dropmann, A Piiper, EA Alonso, S Weber, K Abshagen, M Wieland, S Nittka, K Breitk-Heinlein, M Janicot, F Jaschinski, H Korhonen, S Dooley
Ausgabe
Heft 01 / 2014
Seiten
–
Erschienen: 2014-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0033-1360882

Zusammenfassung

TGF-β1 is a pro-fibrogenic cytokine in chronic liver diseases (CLD), driving fibrogenesis. Many experimental approaches to tackle fibrogenesis were directed towards TGF-β1 and provided promising results. However, none of these could be translated into clinical trials for patient treatment up to now. In contrast, clinical trials have been conducted that were directed against TGF-β2. Participation of TGF-β2 in mechanisms of CLD progression and HCC was first determined on mRNA expression levels in comparison to TGF-β1. TGF-β2 is expressed in hepatic stellate cells (HSC) and hepatocytes (HC) from mouse. TGF-β2 expre…

Schlagworte

Zeitschrift für Gastroenterologie