Hepatic FATP4-deficiency causes alterations in lipid metabolism

Aims and background: Fatty acid transport protein 4 (FATP4), a member of the acyl-CoA synthetase family, is known for its function in complex lipid metabolism. FATP4-deficient mice die shortly after birth due to alterations in skin architecture leading to a restrictive ventilatory disorder and transepidermal water loss. Adipocyte-specific FATP4 knockout mice showed a larger fat mass but lower levels of various phospholipid subtypes compared to control littermates. Therefore, the obvious question is what role FATP4 plays in other high lipid turnover tissues. The objective of this study is to clarify the function…