Hematopoietic cells-derived Jnk1 drives hepatic injury and hepatocellular carcinoma in IKKγ/NEMO-deleted livers
FJ Cubero, G Zhao, YA Nevzorova, M Al Masaoudi, J Verdier, J Peng, F Schaefer, M Hatting, N Hermanns, MV Boekschoten, C Grouls, N Gassler, F Kiessling, M Muller, C Liedtke, C Trautwein · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aims: Currently the focus of future targeted therapy is to define novel pathways involved in the promotion of the survival and/or death of transformed hepatocytes and the control of their progression into HCC. Of particular interest is the interaction between mechanisms controlling NEMO, the regulatory subunit of NF-κB, and Jnk activation for directing cell death and survival. In the present study, we aimed to define the relevance of Jnk in hepatocyte-specific NEMO knockout mice (NEMOΔhepa), a genetic model of chronic inflammatory liver injury. Methods: We generated global Jnk1-/-/NEMOΔhepa and Jnk2…
