Echogenicity of basal ganglia structures in different phenotypes of Huntington's disease

Introduction: In Huntington's disease (HD), a neurodegenerative inherited disease, chorea as the typical kind of movement disorder is described. Beside chorea, however, all other kinds of movement disorders, such as bradykinesia, dystonia, tremor or myoclonus can occur. Aim of the current study was to investigate alterations in the echogenicity of basal ganglia structures by transcranial sonography (TCS) in different Huntington's disease phenotypes. Method: 45 patients with manifest and genetically confirmed HD were recruited. All participants underwent a thorough neurological examination. For classification int…