Prediction of incident diabetes mellitus or coronary artery disease by atypical sphingoid bases

Sphingolipid de-novo biosynthesis is initiated by the condensation of palmitoyl-CoA and serine by the serine palmitoyltransferase (SPT). Besides these canonical substrates, SPT can also metabolize other acyl-CoAs and other amino acids, thereby generating atypical sphingoid bases. We here investigated the predictive potential of these atypical sphingoid bases for the incidence of coronary artery disease (CAD) events and type 2 diabetes mellitus (T2DM). 349 Subjects enrolled in this study were followed up for 8 years. The plasma sphingoid base profile was analyzed using LC/MS. Confirming our previous results, we f…