Characterization of lipophilic house dust mite-allergens with regard to the allergic phenotype

The common causes for respiratory allergies and allergic asthma are house dust mites (HDM). Not all HDM-allergic patients are detected by use of commercially available aqueous HDM-extract. Especially with regard to lipophilic allergens a lot of information is still lacking which is due to their low concentration in the respective extracts or because they are hidden in a complex matrix. However, there is evidence from other allergen sources that lipophilic allergens are associated with severe clinical reactions. For studying these allergens in more detail as probable cause for HDM-asthma and for improving diagnos…