Endogenous Fgfr2b ligands are dispensable for fibrosis formation and resolution in bleomycin-injured mice
B MacKenzie, D Al Alam, I Henneke, E El Agha, J Quantius, CM Chao, J Wilhelm, M Königshoff, S Herold, W Klepetko, A Günther, W Seeger, S Bellusci · Pneumologie · 2014 · Heft 06
Bibliografische Angaben
Zusammenfassung
Increased fibroblast growth factor 10 (Fgf10) expression in vivo and administration of exogenous FGF7 recombinant protein enhance lung repair due to bleomycin injury by sending survival signals to lung epithelial cells via tyrosine kinase fibroblast growth factor receptor 2b (Fgfr2b). Given the therapeutic effects of these ligands during bleomycin injury, we hypothesized that activation of the Fgfr2b endogenous pathway is critical for lung repair. Furthermore, as new studies for the treatment of Idiopathic Pulmonary Fibrosis (IPF) have begun to target tyrosine kinase receptors, we aimed to 1) assess the levels o…
