In vivo effects of TGF-β1 in lung surfactant regulation, lung meachanics amd structure
E Lopez-Rodriguez, C Boden, S Knippenberg, A Pascual, J Perez-Gil, M Kolb, J Gauldie, U Maus, M Ochs, L Knudsen · Pneumologie · 2014 · Heft 06
Bibliografische Angaben
Zusammenfassung
Transforming growth factor beta 1 (TGF-β1) is a signalling protein with a wide range of biological activities. TGF-β1 is thought to have a pivotal role in fibrogenesis, where TGF-β1 induces myofibroblast migration and increases extracellular matrix synthesis, including collagen. Moreover, it has been described that TGF-β1 is a negative modulator of the regulation of surfactant associated proteins A (SP-A), B (SP-B) and C (SP-C) in vitro. Pulmonary surfactant is a lipid-protein complex that lowers surface tension at the respiratory air-liquid interface, stabilizing the lungs against physical forces tending to col…
