Increased frequencies of activated effector CD4+ T cells in the peripheral blood and hepatic tissue of patients with NAFL and NASH
M Rau, AK Schilling, J Meertens, I Hering, T Kudlich, C Jurowich, N Beyersdorf, A Geier · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) ranges between 20 – 35% in Europe. In 5 to 20% there is a progression from non-alcoholic fatty liver (NAFL) to a non-alcoholic steatohepatitis (NASH) but it is still not understood why some people develop NASH. The current hypothesis about the pathogenesis is a two hit theory. The “first hit” causes a steatosis and the “second hit” in form of bacterial translocation leads to an inflammation and the development of NASH. Hepatic Th17 cell infiltration was observed in a NASH mouse model and higher IL-17 and IL-21 gene expression in human liver…
