A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease
HD Nischalke, P Lutz, B Krämer, T Müller, J Rosendahl, J Fischer, T Berg, M Soyka, N Semmo, J Nattermann, T Sauerbruch, CP Strassburg, F Stickel, U Spengler · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: The genetic background of alcoholic liver diseases and its complications is increasingly recognized. A common polymorphism in the neurocan (NCAN) gene, which is known to be expressed in neuronal tissue, has been identified as risk factor for non-alcoholic fatty liver disease (NAFLD). We investigated if this polymorphism may also be related to alcoholic liver disease (ALD) and hepatocellular carcinoma (HCC). Methods: We analysed the distribution of the NCAN rs2228603 genotypes in 356 patients with alcoholic liver cirrhosis, 126 patients with alcoholic HCC, 382 persons with alcohol abuse witho…
