Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis
J Hartl, H Ehlken, C Weiler-Normann, M Sebode, R Zenouzi, N Pannicke, AW Lohse, C Schramm · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: In autoimmune hepatitis (AIH), relapse rates as high as 90% have been reported after treatment withdrawal. We therefore investigated, whether longer duration of treatment and proper patient selection could increase the long-term success rates of treatment withdrawal. Methods: Following our previously published experience, treatment withdrawal was considered when biochemical remission was maintained under immunosuppressive monotherapy for at least 2 years. Biochemical remission, loss of remission and relapse were defined as suggested in the recent AASLD guidelines. Results: Out of 288 patient…
