Combination therapy with chemotherapeutics and oncolytic measles vaccine viruses as a new option for the treatment of pancreatic cancer

Current therapeutic options for locally advanced or metastatic pancreatic cancer still are not able to improve the prognosis of patients significantly. Thus, it is more than urgent to find new strategies to overcome therapeutic resistance by establishing novel combinatorial approaches encompassing new therapeutic principles. Oncolytic virotherapy with vaccine viruses employs replicative vectors which infect quite selectively tumor cells leading in there to massive virus replication and production of huge amounts of progeny virus particles, followed by tumor cell death (oncolysis). Measles vaccine virus (MeV) alr…