Time-restricted activation of Protein Kinase D2 directs vasculogenesis during mouse embryonic stem cell differentiation
M Müller, J Schroeer, N Azoitei, F Genze, A Illing, T Seufferlein, S Liebau, A Kleger · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
The protein kinase D (PKD) isoenzymes PKD1, -2, and -3, are prominent downstream targets of PKCs and phospholipase D in various biological systems. Recent data from our laboratory identified PKD isoforms as novel, essential mediators of tumour cell-endothelial cell communication but also as regulators of tumour cell motility and metastasis formation. The role of PKD isoforms during vascular development remains elusive. In the current study, we aimed to dissect this contribution using mouse embryonic stem (ES) cells as bona fide tool. First, we identified Protein Kinase D2 as the predominant isoform in undifferen…
