CareLit Fachartikel

Polymorphisms in the RANK/RANKL genes and their effect on bone specific prognosis in breast cancer patients

A Hein, CM Bayer, MG Schrauder, L Häberle, K Heusinger, R Strick, M Ruebner, MP Lux, SP Renner, R Schulz-Wendtland, AB Ekici, A Hartmann, MW Beckmann, PA Fasching · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09

Dokument
932651
CareLit-ID
Jahr
2014
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
A Hein, CM Bayer, MG Schrauder, L Häberle, K Heusinger, R Strick, M Ruebner, MP Lux, SP Renner, R Schulz-Wendtland, AB Ekici, A Hartmann, MW Beckmann, PA Fasching
Ausgabe
Heft 09 / 2014
Seiten
–
Erschienen: 2014-09-05 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0034-1388372

Zusammenfassung

The receptor activator of NF-κB (RANK) pathway is involved in bone health as well as breast cancer (BC) pathogenesis and progression. Whereas the therapeutic implication of this pathway is established for the treatment of osteoporosis and bone metastases, the application in adjuvant BC is currently investigated. As genetic variants in this pathway have been described to influence bone health, aim of this study was the prognostic relevance of genetic variants in RANK and RANKL. Single nucleotide polymorphisms (SNPs) in RANK(L) (rs1054016/rs1805034/rs35211496) were genotyped and analyzed with regard to bone metast…

Schlagworte

Breast Alleles Allele Geburtshilfe und Frauenheilkunde