Weekly simultaneous 24h infusion of high-dose 5-fluorouracil and sodium folinate as salvage therapy for recurrent ovarian cancer – a case report

Introduction: Despite any modern therapies, approximately 80% of patients with ovarian cancer relapse. Unresectable recurrent ovarian cancer is usually treated by cytotoxic chemotherapy including carboplatin combinations (for platin-sensitive disease) or monotherapy with e.g. paclitaxel, pegylated liposomal doxorubicin, gemcitabine or treosulfan (for platin-resistant disease). Response rates to chemotherapy vary between 8 to 50% depending on the number of previous therapies. Although chemotherapy in recurrent disease still failed to show prolongation of overall survival, it still seems beneficial for prolonging…