Lineage fate of ductular reactions in liver injury and carcinogenesis
S Jörs, P Jeliazkova, M Ringelhan, J Thalhammer, S Dürl, J Ferrer, M Sander, M Heikenwälder, RM Schmid, JT Siveke, F Geisler · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Ductular reactions (DRs) are observed in virtually all forms of human liver disease. Nevertheless, the histogenesis and function of DRs in liver injury are not entirely understood. It is widely believed that DRs contain bipotential liver progenitor cells (LPCs) that serve as an emergency cell pool to regenerate both, cholangiocytes and hepatocytes, and may eventually give rise to hepatocellular carcinoma (HCC). Here we provide a thorough analysis on the histogenesis of DRs and their potential contribution to liver regeneration and carcinogenesis. Using a mouse model that allows highly efficient and specific line…
