CareLit Fachartikel
Endocytosis of the signal transducing receptor gp130 as mechanism to fine-tune IL-6 responses
HM Hermanns, C Mais, S Walter, A Geier · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Dokument
933040
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
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Zusammenfassung
Background and aims: The restriction of cytokine signalling in strength and duration is of fundamental importance to limit inflammation. We identified a cross-talk mediated endocytosis by which pro-inflammatory stimuli can influence the responsiveness of liver cells for cytokines of the IL-6 family. Methods: HepG2 hepatoma cells were treated with the pro-inflammatory cytokine IL-1β for different periods of time. IL-1β-mediated signalling was characterized by Western blotting. Cell surface expression of gp130 was analyzed by flow cytometry and live cell imaging. To identify the signalling pathway responsible for…
Schlagworte
Cytokine
Clathrin-Coated Vesicles
Amino Acids
Cytokines
Clathrin
Axis
Zeitschrift für Gastroenterologie
