Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model
FJ Cubero, M Hatting, M Spannbauer, J Peng, W Hu, M Al Masaoudi, G Sellge, N Gassler, C Liedtke, C Trautwein · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background & Aim: Chronic liver inflammation is a crucial event in the development and growth of hepatocellular carcinoma (HCC). Compelling evidence has shown that IL-6/gp130-dependent signaling plays a fundamental role in liver carcinogenesis. Thus, in the present study we aimed to investigate the role of gp130 in hepatocytes for the initiation and progression of HCC. Methods: Hepatocyte-specific gp130 knockout mice (gp130Δhepa) and control animals (gp130f/f) were treated with diethylnitrosamine (DEN). The role of gp130 for acute injury (0 – 5 days), tumor initiation (24 weeks) and progression (40 weeks) was an…
