Primary hepatic malignant epitheloid Hemangioendothelioma represent a genetically homogenous tumor entity

Aims: Epitheloid Hemangioendothelioma (EHE) is a rare malignant vascular tumors of unknown etiology and molecular pathogenesis. It may arise at many different sites, but liver is among the more frequent manifestations. Course of the disease is highly variable and so far only limited therapeutic options are available such as resection and liver transplantation. Our aim is to molecularly characterize this tumor entity in order to find new potential therapeutical targets. Methods: EHEs were histologically classified by two expert liver pathologists and further characterized by immunohistology. Fifteen formaline fix…