The hepatic tumor microenvironment is important for the CSC phenotype and progression of liver cancer
M Fischer, S Heinrich, JB Andersen, D Castven, M Sprinzl, I Gockel, MA Wörns, S Thorgeirsson, PR Galle, H Lang, JU Marquardt · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: The cancer stem cell (CSC) hypothesis is an emerging concept in cancer research that provides a plausible explanation for the observed phenotypic heterogeneity of many cancers, including hepatocellular carcinoma (HCC). Despite profound therapeutic implications, the prognostic relevance of CSCs and their cellular localization within the tumor formation remain controversial. Methods: Localization and expression levels of selected CSC marker were assessed in 30 HCCs using qRT-PCR, imunohistochemistry and Western-Blotting. Whole transcriptome analysis of the central tumor, invasive tumor margin (TM) as w…
