Interleukin-23 but not interleukin-17A promotes the protective effect of adjuvanticity of Trehalose-6,6-dibehenate for subunit Mycobacterium tuberculosis vaccination

Einleitung: Human Tuberculosis (TB), caused by the gram-positive bacterium Mycobacterium tuberculosis (Mtb), still remains a major cause of morbidity worldwide leading to 1.4 million deaths annually. The currently most efficient vaccine against TB is the live vaccine Mycobacterium bovis (BCG). However, its protective effect is limited and the development of new vaccination strategies that already inhibit the initial establishment of infection is of great importance. Adjuvants are essential to support a T cell-mediated immune response to protein antigens. The novel glycolipid adjuvant Trehalose-dibehenate (TDB),…