The macrophage migration inhibitory factor (MIF)/CXCR4 axis regulates migration of bone marrow derived mesenchymal stem cells towards pancreatic ß-cells under lipotoxic conditions
B Mihic-Necic, S Taromi, C Liu, J Straetener, M Ihle, D Kriedemann, M Hille, AE Mehana, K Laubner, N Perakakis, G Päth, J Seufert · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background and aim: Mesenchymal stem cells (MSCs) bare the ability to home to sites of injury where they act by secreting angiogenic- and immunomodulatory factors. Previously we demonstrated that human telomerase-immortalised MSCs (hMSC-TERT) migrate towards injured INS-1E ß-cells, where they preserve cellular viability. Here we identify macrophage migration inhibitory factor (MIF) secreted by injured ß-cells as chemotactic factor that supports migration of MSCs. Materials and methods: Chemotaxis assay was performed using microchemotaxis system ChemoTx. hMSC-TERT were allowed to migrate through 8-µm pore size me…
