Adipose tissue specific adipose triglyceride lipase influences the development of pressure overload-induced heart failure

Introduction: Cardiac metabolism undergoes changes in response to pathological hypertrophy (PH), characterized by increased reliance on glucose and decreased free fatty acid (FFA) oxidation. Also cardiac metabolism is influenced by other organs such as adipose tissue (AT). We aimed to investigate the effect of Adipose Triglyceride Lipase (ATGL) in AT on the development of PH in a pressure overload-induced cardiac hypertrophy model in mice. Methods: Adipose tissue specific ATGL-knock out (atATGL-KO) and wild type mice (WT) underwent transverse aortic constriction (TAC) or sham surgery. We performed echocardiograp…