Engineering the optimal site for islet cell transplantation: proof-of-concept for a decellularized rat pancreas
H Napierala, B Strücker, KH Hillebrandt, P Tang, D Polenz, A Reutzel-Selke, S Lippert, M Kluge, N Raschzok, J Pratschke, IM Sauer · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: A cell based treatment for type 1 diabetes can significantly reduce the occurence of life-threatening complications, like hypoglycemic episodes, and progression of diesease-associated co-morbidities. Islet cell transplantation is able to achieve insulin independence in 40 – 60% of cases. But unfortunately graft-site-specific issues still remain a major obstacle. The aim of this study was to address them by engineering a decellularized pancreas graft, which could be used for the engineering of an endocrine Neo-Pancreas. Methods: Pancreata from 32 Fisher DPP-IV- rats (m/f, 150 – 550 g) were retrieved…
