Lipocalin-2 in degenerative Retinopathy

The impact of disease-associated changes in gene expression involved in retinopathies depends on their spatial distribution within the retina. Lipocalin-2 (Lcn-2) is exclusively expressed in the inner retina of rats developing neurovascular degenerations similar to diabetic retinopathy (PKD2). However the function of Lcn-2 in the development of retinopathy remains unclear. This project aims at the specific localization of Lcn-2 and the identification of possible links to degenerative retinopathies. We used immunofluorescence stained cryosections of PKD2 and Sprague Dawley rats colocalizing Lcn-2 with GFAP and γ-…