Functional annotation of obesity SNPs underlying potential parent of origin effects

Genome-Wide Association Studies (GWAS) were successfully applied to discover genetic variants associated with obesity. However, only part of the heritability is explained. Analyses of potential parent of origin effects (POE) may provide further insights into the genetic mechanisms of obesity. The aim of the study was to identify novel functional SNPs/regions which are likely contribute to obesity. Here, Genome wide genotypes from Sorbs (N= 525), a German self-contained population, were phased using AlphaImpute. Three different GWAS were applied in PLINK: (i) standard association, (ii) considering paternal and (i…