New insulin glargine 300 U/mL: Glycemic control and hypoglycemia in a meta-analysis of EDITION clinical trials in people with T2DM

Background and aims: The EDITION 1, 2 and 3 studies compared the efficacy and safety of new insulin glargine 300 U/mL (Gla-300) with insulin glargine 100 U/mL (Gla-100) in people with type 2 diabetes mellitus on basal and mealtime insulin, basal insulin and OADs, and no prior insulin, respectively. A meta-analysis of these studies was conducted to study efficacy and safety. Materials and methods: Meta-analysis of these three studies enabled glycemic control and hypoglycemia to be examined over 6 months in a large, heterogeneous type 2 diabetes mellitus population (Gla-300, N = 1247; Gla-100, N = 1249). Results:…