Direct observed therapy of chronic Hepatitis C with an interferon-free all-oral regimen at a low-threshold drug treatment facility – a new concept for treatment of patients with b…

Background: Patients receiving opioid substitution therapy represent an important subgroup of patients with chronic hepatitis C. Many of these patients suffer from psychiatric comorbidities and thus have contraindications against interferon-based treatment. Furthermore, a significant number of them have a borderline compliance and hence are reluctant to go to specialized hepatitis centers. Patients and Methods: In patients with borderline compliance receiving their opioid substitution therapy at a low-threshold drug treatment facility on a daily basis, modern direct acting antivirals against hepatitis C are appl…