Efficacy and safety of IFN-free antiviral therapy in patients with HCV recurrence after liver transplantation: real-life experience from Austria

Background & Aims: Patients with hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (OLT) have a high need of antiviral therapy due to accelerated progression of the disease. IFN-free regimens revealed promising efficacy and safety data in clinical studies. We evaluated real-life experience of efficacy and safety of all-oral regimens in patients with HCV-recurrence after OLT. Patients & Methods: 77 OLT-patients and 5 with liver/kidney-transplantation started an all-oral anti-HCV treatment. 68 beyond treatment-week 4 were analyzed (male: 54/79%, age: 59 ± 9 [33 – 78] years, GT-1: 51 [1a: 13…