Ultra-high-field MR-spectroscopy in NAFLD as in-vivo tool for monitoring changes in fat and energy metabolism with potential identification of NASH and advanced fibrosis by satura…
S Traussnigg, C Kienbacher, M Gajdošík, M Gajdošík, L Valkovič, P Ferenci, F Wrba, J Stift, S Trattnig, M Krššák, M Trauner · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and Aims: With the rising incidence of NAFLD with potentially progressive steatohepatitis (NASH) non-invasive tools for risk stratification and treatment response assessment are urgently needed. We therefore used high-field magnetic-resonance-spectroscopy (MRS) as non-invasive tool to obtain novel mechanistic and pathogenetic insights into alterations of hepatic metabolism in NAFLD. Methods: MRS and liver biopsy were performed back-to-back in suspected NAFLD and data were correlated with histology. Hepatocellular lipid content (HCL) was measured by 1 H-MRS. 7.0-T 31P-MRS was applied to determine phosp…
