Expression of CCL22 and Infiltration by Regulatory T Cells are increased in the Decidua of Human Miscarriage Placentas

Problem: Regulatory T cells (Treg) are a T cell subpopulation with suppressive capacities, specifically attracted by CCL22. We aimed to investigate whether CCL22 is expressed in human placentas and whether its presence, together with Treg infiltration, is associated with miscarriage conditions. Method of study: Paraffin samples were stained for CCL22 and for the Treg specific transcription factor FoxP3. Expression levels were evaluated in a semi-quantitative manner. Double immunofluorescence was used for the identification of CCL22-producing cells. Results: In all placentas, trophoblasts expressed CCL22. Interes…