Chemosensory cholinergic signaling network in the thymic medullary epithelium
A Soultanova, A Panneck, A Rafiq, B Schütz, V Chubanov, T Gudermann, E Weihe, G Krasteva-Christ, H Müller-Redetzky, M Witzenrath, A Voigt, W Meyerhof, W Kummer · Pneumologie · 2015 · Heft 07
Bibliografische Angaben
Zusammenfassung
Cholinergic signaling influences T cell maturation, and acetylcholine is endogenously synthesized in the thymus. Utilizing a reporter mouse strain that expresses GFP under the promoter of the acetylcholine synthesizing enzyme, choline acetyltransferase (ChAT), we detected cholinergic cells in the thymic medulla. Using additional reporter mouse strains and immunohistochemistry, we show that ChAT-positive cells co-express the bitter taste receptor Tas2R131 and the components of taste signaling cascade α-gustducin, phospholipase Cβ2 and the cation channel TRPM5. These thymic cholinergic chemosensory cells are diffe…
