Impact of epidermal growth factor receptor (EGFR) inhibitors on cisplatin-resistant non-small cell lung cancer (NSCLC) cell lines in parallel to naïve cells at therapeutic doses

Introduction: Chemotherapy represents the backbone of treatment of advanced NSCLC; a platinum-based doublet is standard in first-line treatment. But resistance limits the effectiveness of anticancer drugs and is the major cause of relapse and cancer mortality. Cisplatin activates membrane-integrated proteins, like the EGFR. As in more than 60% of NSCLC s EGFR is overexpressed and in about 10% activated by a driver mutation, EGFR is a further target. We tested whether EGFR TKIs influence cisplatin resistance (CR). Methods: For the experiments H838 (wild type EGFR), HCC827 (delE746-A750) and H1975 (L858R, T790 M)…