Removal of soluble Fms-like tyrosine kinase (sFlt-1) by plasma-specific apheresis: pilot study in women with very preterm preeclampsia
W Schaarschmidt, H Hagmann, B Roth, T Cingoez, A Karumanchi, J Wenger, KJ Lucchesi, H Tamez, T Lindner, A Fridmann, U Thome, A Kribs, M Danner, S Hamacher, P Mallmann, H Stepan, T Benzing, R Thadhani · Zeitschrift für Geburtshilfe und Neonatologie · 2015 · Heft 11
Bibliografische Angaben
Zusammenfassung
Background: Soluble Fms-like tyrosine kinase-1 (sFlt-1) is a potential therapeutic target in preeclampsia. We evaluated the safety and efficacy of treating women with very preterm preeclampsia using a plasma-specific dextran sulfate (PSDS) column to remove circulating sFlt-1. Methods: This was an open study of up to three extra-corporeal PSDS-apheresis treatments in 10 women with very preterm preeclampsia to determine the extent of sFlt-1 and proteinuria reduction, and its safety for mother and fetus. Results: Six patients with very preterm preeclampsia (mean gestational age 29 + 2 weeks) underwent one PSDS-aphe…
