Peripartal blood loss and outcome of intrahepatic cholestasis of pregnancy

Aim: Intrahepatic cholestasis of pregnancy (ICP) is associated with preterm birth, meconium staining and stillbirth. In addition, increased blood bile acids (BBA) may cause vitamin K malabsorption and hence influence blood coagulation with increased peripartal blood loss. Our goal was to evaluate feto-maternal outcome in women with ICP with attention to peripartal blood loss. Methods: In a retrospective case-control study, 15083 deliveries including 345 women with ICP (2,3%) were analyzed from 2004 – 2014. To adjust differences in baseline characteristics a propensity analysis was performed and controls were mat…