Glycosylated hemoglobin (HbA1c) in the first trimester of pregnancy

Introduction: Glycosylated hemoglobin (HbA1c) is a form of hemoglobin that characterises a patient's plasma glucose over a prolonged period of time. The American Diabetic Association (ADA) supported the use of HbA1c as an option for the diagnosis of diabetes. A value of ≥6.5% was proposed as the criterion for diagnosis. A partial aim of our study was to assess if a first trimester HbA1c value of 5.7 – 6.4% (prediabetes) could be an early predictor of progression to gestational diabetes mellitus (GDM). Methods: This is a prospective cohort study performed on all women who delivered at a single institution over 1.…