Changes in lipid and carbohydrate metabolism under mTOR- and calcineurin-based immunosuppressive regimen in adult patients after liver transplantation

Background: Cardiovascular disease is a leading cause of long-term mortality after liver transplantation (LT). Life long immunosuppression harbours the risk of metabolic alterations. We aimed to analyze the impact of calcineurin (CNI)-only containing regimen (group A) compared to mTOR-containing regimen (group B) on lipid and carbohydrate metabolism. Patients/methods: 92 adult patients after LT, University of Mainz (group A - 78 patients, group B - 14 patients; 65 M/27F; mean age 59+/-10.2 ys; mean time from LT 5.8+/-5 ys). Clinical data, comorbidities, medication were assessed. Fasting lipid profile including s…