Keratin 23 represents a novel liver injury marker reflecting the severity of ductular reaction
N Guldiken, G Kobazi Ensari, P Lahiri, C Liedtke, HW Zimmermann, C Trautwein, M Ziol, P Strnad · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Keratins (K) are the intermediate filaments of epithelial cells and constitute established diagnostic tools. In the liver, K7/K19 expression is restricted to hepatic progenitor cells (HPCs) and biliary epithelial cells (BECs). Consequently, K7/K19 represent a widely used marker of the regenerative liver response termed ductular reaction (DR) that consists of activated BECs and HPCs. Methods: Since K23 is a largely unknown keratin family member, we analysed its expression and localization in selected human liver disorders and mouse liver injury models using custom-made antibodies. Serum K23 levels were measured v…
