Tumor infiltrating B cells producing antitumor active immunoglobulins in resected hepatocellular carcinoma prolong patient survival
SM Brunner, T Itzel, C Rubner, R Kesselring, E Griesshammer, P Rümmele, A Teufel, HJ Schlitt, S Fichtner-Feigl · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background: The immunological microenvironment of hepatocellular carcinoma (HCC) influences patient outcome, however, the role of B cells remains unclear. This study investigated effects of local B-cell infiltration in HCC cohorts on patient survival and immunological and molecular tumor microenvironment. Methods: Gene expression of 2 independent HCC tissue databases was compared using microarrays. Tissue of resected HCCs was stained for H&E, CD20, CD79a, CD138 and immunoglobulins. Besides histomorphologic evaluation, the immunohistochemical stainings were analysed for the respective cell numbers separately for…
