Neue Therapieansätze bei hypoxisch-ischemischem Hirnschaden

Dysfunction and loss of neurons are the major characteristics of CNS disorders that include stroke, multiple sclerosis, Alzheimer's disease, and perinatal brain injury. Perinatal brain injury is a major cause of neonatal death and long-term disability and successful therapeutic approaches are lacking. PreImplantation Factor (PIF) can be detected in the maternal circulation during pregnancy and its presence has been correlated with live birth. PIF has been implicated in promoting embryo implantation through modulating maternal immune tolerance. Consistent with the immune function, a synthetic PIF analog (sPIF) en…