Role of Long-term Physical Activity on Mouse Lung

Despite the known positive effects of moderate endurance exercise, there is increasing evidence that continuous physical activity can results in airway inflammation and bronchial epithelial damages. Therefore, we studied biomechanical parameters and airway inflammatory response of lungs from mice after long-term voluntary exercise and their dependency on the pulmonary receptor for advanced glycation end-products (RAGE). Method: C57BL/6 wild-type (WT) and RAGE knock out (RAGE-KO) mice run for 9 months in a wheel-running system on voluntary basis. Thereafter, lung biomechanics and airway responsiveness to acetylch…