Interferons suppress IL-1beta dependent GM-CSF in post-influenza pneumococcal infection of human lungs
K Zscheppang, J Berg, D Fatykhova, M Tönnies, TT Bauer, P Schneider, J Neudecker, J Rückert, S Eggeling, M Schimek, A Gruber, N Suttorp, S Hippenstiel, AC Hocke · Pneumologie · 2016 · Heft 02
Bibliografische Angaben
Zusammenfassung
The severity and lethality in influenza A virus (IAV) infections is frequently aggravated by secondary bacterial pneumonia. However, mechanisms in human lung tissue provoking this increase in fatality are unknown. We established a human lung ex vivo co-infection model to investigate innate immune related mechanisms contributing to the susceptibility of secondary pneumococcal pneumonia. We observed induction of type I, II, and III interferons (IFN) in alveolar epithelial type II cells (AEC II) after IAV infection and revealed their inhibitory effect on Streptococcus pneumoniae (S. pneumoniae) induced IL-1β releas…
