Time course of changes in skeletal muscle oxidative capacity and relation to insulin sensitivity and metabolic flexibility after gastric bypass and gastric sleeve surgery

Background: Bariatric surgery may improve skeletal muscle mitochondrial function and insulin sensitivity, but impact of type of surgery and time course of changes remain unclear. Methods: We quantified skeletal muscle mitochondrial respiration using high resolution respirometry and peripheral insulin sensitivity (M-value) using hyperinsulinemic-euglycemic clamps combined with indirect calorimetry for assessment of metabolic flexibility (ΔRQ = RQ clamp-RQ baseline). Results: Obese patients were studied before, two weeks, three, six and twelve months after gastric sleeve (GS; n = 8 age 41 ± 12yrs, BMI 52.6 ± 10 kg…