Effect of Biochanin A on serum nesfatin-1 Level in STZ induced type 1 diabetic rat

Introductions: Hypoglycemic effect of bioflavonoids have been approved, they can act as insulin secretagogues or insulin mimetics. Nesfatin-1 is a recently discovered regulatory peptide and affects glucose metabolism by increasing insulin sensitivity. In this study we investigated effect of Biochanin A (an isoflavonoid) on serum nesfatin-1 level in streptozotocin (STZ)-induced type 1 diabetic rats. Material and methods: 30 male Wistar rats were divided randomly into five groups. Two groups of them were selected randomly as control. Group1: normal control (receiving 0.5% DMSO), Group2: normal control that receivi…