Radiogenomic rCBV-imaging visualizes the moleculare signature of IDH-mutant and wildtype gliomas
P Kickingereder, P Kickingereder, F Sahm, A Radbruch, W Wick, S Heiland, A von Deimling, M Bendszus, B Wiestler · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2016 · Heft 03
Bibliografische Angaben
Zusammenfassung
Zielsetzung: The recent identification of isocitrate dehydrogenase (IDH) mutations in gliomas and several other cancers suggests that this pathway is involved in oncogenesis; however effector functions are complex and yet incompletely understood. To study the regulatory effects of IDH on hypoxia-inducible-factor 1-alpha (HIF1A), a driving force in hypoxia-initiated angiogenesis, we performed mRNA-expression and genotype/imaging phenotype correlation analysis. Material und Methodik: We studied differenzial mRNA expression profiles from 288 samples with low-grade diffuse and anaplastic gliomas from The Cancer Geno…
