Circulating levels of Pro-C3 reflect liver fibrosis and function in HIV positive patients receiving cART
L Dold, MJ Nielsen, C Luda, C Schwarze-Zander, C Bösecke, R Schierwagen, C Jansen, HD Nischalke, JC Wasmuth, CP Strassburg, JK Rockstroh, U Spengler, J Trebicka, DJ Leeming · Zeitschrift für Gastroenterologie · 2016 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: Although combined antiretroviral treatment (cART) has improved overall survival of HIV infected patients, liver fibrosis and liver related-mortality still constitute major challenges in HIV positive patients. Collagen type III accumulates in the liver during fibrogenesis. Recent studies could show that circulating levels of fragments of extracellular matrix (ECM) might reflect fibrosis stage and degree of portal hypertension in liver disease. In this study, we analyzed the correlation between liver fibrosis assessed by Fibroscan and levels of the formation marker of collagen type III in HIV…
