The use of pentaerythrityltetranitrate (PETN), a nitric oxide donor, to improve utero- and fetal-placental perfusion pregnancies with established pathological flow pattern in the…

Introduction: NO-donors like Pentaerythrityltetranitrate (PETN) have been shown before to reduce the resistance index (RI) in the Aa. Uterinae (1), but effects on fetal circulation have not been investigated yet. We performed a randomized, prospective, placebo-controlled, double-blind study to investigate the influence of PETN in pregnancies presenting with persistent high uterine resistance in mid-gestion (2) and analyzed now the effects on uteroplacental and fetoplacental perfusion flow indices. Methods: 111 pregnancies presenting with abnormal placental perfusion (bilateral notch or mean RI> 0.7) between the…