Maternal Acetylcholine-Receptor Autoantibodies causing recurrent fetal Arthrogryposis

Background: The foetal Arthrogryposis multiplex congenita is defined as the occurrence of malposition of two joints in at least two body regions. This descriptive definition comprises a multitude of genetic and non-genetic causes. The detection of the underlying aetiology is reported to be approximately 5%. A rare non-genetic cause of foetal Arthrogryposis is a maternal myasthenia gravis or maternal autoantibodies against the Acetylcholine-Receptor (AChR-AA). By passing the placenta, they cause foetal akinesia deformation sequence. Case report: A healthy 28-year-old primigravida presents in 13 weeks of gestation…