Dasatinib treatment results in a markedly diminished frequency of bone metastases after intracardiac injection of osteotropic MDA-MB-231 breast cancer cells in a xenograft mouse m…
T Heilmann, M Roscher, AL Rumpf, M Gerle, M Tietgen, O Will, T Damm, N Maass, CC Glüer, S Tiwari, A Trauzold, C Schem · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Aims: The development of skeletal breast cancer metastases depends on tumor cell Src-kinase activity. We were recently able to show that knockdown of TRAIL (TNF related apoptosis inducing ligand)-R2 in an osteotropic clone of MDA-MB-231 cells results in a diminished frequency of bone metastases by an impairment of homing mechanisms after intracardiac injection in a xenograft-mouse model. In vitro we also found a downregulation of Src kinase levels in these cells. We therefore aimed to examine a conceivably synergistic effect on the development of breast cancer bone metastases after treatment with Dasatinib, a ty…
